近日，广东工业大学环境健康与污染控制研究院、环境科学与工程学院唐僭博士生等在皮肤暴露半挥发性有机污染物(SVOCs)方面取得最新研究进展，研究成果以《Identifying Dermal Uptake as Significant Pathway for Human Exposure to Typical SVOCs in an E-Waste Dismantling Site: The Relationship of Contaminant Levels in Handwipes and Urine Metabolites》为题发表在Environmental Science & Technology上。该工作系统地评估了某典型电子垃圾回收地区的拆解工人和周边居民通过皮肤接触暴露于三种典型的SVOCs（PAHs、OPFRs和PBDEs）的贡献。通过多化合物对比研究，揭示了不同化合物的理化性质造成的皮肤暴露差异，并发现磷酸三苯酯(TPhP)可作为电子垃圾拆解区人群皮肤暴露的特征污染物；通过对比不同人群的暴露特征以及多途径暴露的贡献，揭示了电子垃圾拆解职业暴露人群皮肤暴露的重要性。

论文的网址： https://doi.org/10.1021/acs.est.1c02562

近年来，毒害有机物的皮肤接触暴露引起了广泛关注。对于部分半挥发性有机污染物(SVOCs)而言，个体通过皮肤接触暴露的SVOCs与大气呼吸途径相当甚至可能占比更高。SVOCs的皮肤暴露可通过直接接触物品及表面灰尘或直接从空气经皮吸收。擦手样品作为一种非侵入性手段常被用作SVOCs皮肤暴露样品的采集和评估。在本研究中，我们采集了典型电子垃圾拆解区的暴露工人（直接从事电子垃圾拆解的工人和非直接的电子垃圾园区的管理服务人员）和附近居民（成年居民和青少年居民）共89份配对的擦手样品和尿液样品。对擦手样品中三种典型的SVOCs：PAHs、OPFRs和PBDEs进行了分析。发现来自电子垃圾拆解工人的擦手样品中PAHs、OPFRs和PBDEs的中位数水平分别为96.0、183和238 ng。拆解工人擦手样品中的SVOCs的暴露水平显著高于附近居民，这表明直接参与电子垃圾拆解活动相关的暴露个体遭受了更多的皮肤暴露。在三种SVOCs中，擦手样品中的TPhP和配对尿样中的磷酸二苯酯(DPhP)之间的相关性最强；其次是PAHs和PBDEs与其相应的尿液代谢物之间的相关性；进一步研究发现电子垃圾拆解工人的擦手样品中TPhP与尿液中DPhP含量相关性大于管理人员及周边居民，表明TPhP是电子垃圾拆解人群皮肤暴露的特征标志物。对比多途径暴露的贡献，发现TPhP通过皮肤暴露对电子垃圾拆解工人的暴露贡献最大。本研究强调了在典型的电子垃圾拆解区职业皮肤暴露于TPhP的重要性，这应该在SVOCs未来的暴露风险评估中具有非常重要的研究意义。

图文摘要：

英文摘要：

Dermal exposure to semi-volatile organic compounds (SVOCs) has recently attracted widespread attention; understanding these exposures is particularly important for people whose skin is frequently exposed to different pollution surfaces. In this study, handwipes were collected from exposed occupational workers and local residents near a typical electronic waste (e-waste) dismantling area; urine samples were also sampled. The wipes were analyzed for three typical SVOCs: polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and organophosphate flame retardants (OPFRs). The median levels of PAHs, OPFRs and PBDEs in handwipes from e-waste dismantlers were as 96.0, 183, and 238 ng, respectively. The analytes were higher in the handwipes collected from workers than residents, indicating that they were subjected to greater dermal exposure during primitive e-waste dismantling activities. Among the three SVOCs, the strongest correlation was found between triphenyl phosphate (TPhP) in handwipes and diphenyl phosphate (DPhP) in paired urine; the next strongest correlations were between PAHs and PBDEs and their corresponding urinary metabolites. The results showed TPhP contributed the highest exposure to e-waste dismantlers via dermal exposure. Our research highlights the importance of dermal exposure to TPhP, which should be considered in future exposure risk assessments.

资助项目：本研究得到国家自然科学基金（41731279、41991310、41703092和41907363）、国家重点研发项目（2019YFC1804503）、广东省本土创新科研团队（2017BT01Z032）的支持。