典型有机磷阻燃剂体外暴露对人体不同呼吸系统细胞的毒性机制
这是第一篇通过OPFRs暴露下整个人呼吸道的不同呼吸细胞毒性的比较研究,发现HNEpC细胞是TPHP最敏感的靶点。
消毒副产物形成机制方面的最新学术论文
该研究重点针对高毒性碘化消毒副产物(I-DBPs)形成机制不明晰的问题,采用量子化学计算与实验研究相结合的研究手段,从分子水平阐明了I-DBPs形成过程中H2OI+酸催化作用,为减少毒害消毒副产物I-DBPs暴露和健康影响提供了新见解。

沈先涛

2021-12-01

  • 姓名:沈先涛

  •  

  • 职务:教授

  • 院系:公共卫生学院

  • 地址:湖北省武汉市航空路13号 430030

  • 电话:86-27-83610968

  • 邮箱:xtshenlab@hust.edu.cn

个人简介

       20026月在华中科技大学精细化工专业获得学士学位。20071月在华中科技大学分析化学专业获得硕士学位,毕业论文获得湖北省2008年优秀硕士论文(No. 1)。20103月在华中科技大学材料物理与化学专业获得博士学位。2010-2012年在瑞典隆德大学从事博士后研究工作,2013-2014年在挪威G&T Septech公司(奥斯陆大学)从事研究工作。2014-2015年在瑞典马尔默大学担任客座研究员。2015年加入华中科技大学公共卫生学院担任教授。

    主要从事多功能分子识别材料在环境有机污染物、生物蛋白质与肽、生物细胞及微生物的分离及监测等方面的研究工作。近年来先后主持和参与中国、瑞典、挪威、欧盟等多项科研项目,至今发表论文40余篇,合计引用次数超过1300次。

 

研究方向


1. 多功能分离识别材料的制备:分子印迹技术是制备对特定目标分子具有特异性识别性能人工抗体的技术。合成的分子印迹聚合物作为人工抗体可选择性识别富集复杂样品中的目标物。本课题组主要采用Pickering乳液界面聚合方法针对不同目标物质制备一系列人工抗体。

2. 新型分离技术:包括电膜萃取技术的研究、小内径(50微米以下)有机整体色谱柱的制备等前沿分离技术的研究。

3. 环境污染选择性控制新技术:将分子识别技术与常规高级氧化技术结合,合成一系列人工抗体性光催化剂。该光催化剂可选择性降解复杂环境污水体系中高毒性、低浓度有机污染物。

4. 环境污染物暴露的健康效应:研究重金属与环境内分泌干扰物等环境污染物暴露对母婴健康的影响,如对母婴内分泌系统的干扰作用及婴幼儿生长发育的影响。


主要承担的科研项目


1. 国家自然科学基金面上项目:基于分子印迹型MOFs催化剂去除典型抗生素类污染物的研究,2017/01-2020/12, 资助经费:66万元,在研,主持

2. 国家自然科学基金面上项目,基于细菌趋化性的第二代细菌印迹技术研究,2019/01-2022/12, 资助经费:64万元,在研,主持

3. 华中科技大学自主创新研究基金:基于分子识别的聚集诱导发光技术在糖尿病代谢标志物检测中的应用研究, 2016/04-2018/12,资助经费: 10万元,已结题,主持

4. 华中科技大学自主创新重点专项项目:多重纳米仿酶催化体系氧化环化生长激素抑制素类环肽的研究, 2015/05-2016/12,资助经费:8万元,已结题,主持

5. 湖北省青年科技晨光计划:分子印迹与电膜萃取联用技术在萃取血浆中的多肽的研究, 2015-2016,资助经费:1万元,已结题,主持


 



代表性论著

一、英文文章

(1) Huang, C.; Shen, X. (co-first author); Liu, X.; Chen, Z.; Shu, B.; Wan, L.; Liu H.; He, J. Hybrid Breath Figure Method: A New Insight in Petri Dishes for Cell Culture. J Colloid. Interf. Sci., 2019, 541:114-122. (IF=5.091)

 

(2) Huang, C.; Shen, X.*; Gjelstad, A.; Pedersen-Bjergaard, S., Investigation of alternative supported liquid membranes in electromembrane extraction of basic drugs from human plasma. J. Membrane Sci., 2018,548, 176-183. (IF=6.578, Times Cited: 5)

 

(3) Lin, B.; Wan, L.; Sun, X.; Huang, C.*; Pedersen-Bjergaard, S.; Shen, X.*, Electromembrane extraction of high level substances: A novel approach for selective recovery of templates in molecular imprinting. J. Membrane Sci.2018, 568, 30-39. (IF=6.578, Times Cited: 1)

 

(4) Wang, S.; Lin, B.; Chen, L.; Li, N.; Xu, J.; Wang, J.;Yan, Y,; Qi, Y.; She, Y.; Shen, X*.; Xiao, X.*, Branch-Migration Based Fluorescent Probe for Highly Sensitive Detection of Mercury. Anal. Chem., 2018, 90 (20), 11764-11769. (IF=6.042)

 

(5) Sun, X.; Li, J.; Jin, S.; Li, Y.; Liu, W.; Zhao, H.; Zhou, Y.; Jiang, Y.; Liu, H.; Xia, W.; Cai, Z.; Xu, S.*Shen, X.*, Associations between repeated measures of maternal urinary phthalate metabolites during pregnancy and cord blood glucocorticoids. Environ. Int.2018, 121, 471-479. (IF=7.297, Times Cited: 1)

 

(6) Sun, X.; Jiang, Y.; Xia, W.; Jin, S.; Liu, W.; Lin, X.; Chen X.; Peng Y.; Li H.; Lu B.; Xu S.; Li Y.*Shen X.*, Association between prenatal nickel exposure and preterm low birth weight: possible effect of selenium. Environ. Sci. Pollut. Res. Int.2018, 25(26), 25888-25895. (IF=2.80)

 

(7) Wan, L.; Chen, Z.; Huang, C.*; Shen, X.* Core-shell molecularly imprinted particles; TrAC, Trends Anal. Chem.2017, 95, 110-121.. (IF= 8.442, Times Cited: 6)

 

(8) Chen, Z.; Sellergren, B.; Shen, X.* Synergistic Catalysis by “Polymeric Microzymes and Inorganic Nanozymes”: The 1+1>2 Effect for Intramolecular Cyclization of Peptides; Front. Chem.2017, 5: 60. (IF= 3.994, Times Cited: 1)

 

(9) Huang, C.*; Chen, Z.; Gjelstad, A.; Pedersen-Bjergaard, S.; Shen, X.* Electromembrane extraction; TrAC, Trends Anal. Chem.2017, 95, 47-56. (IF= 8.442, Times Cited: 14)

 

(10) Shen, X.*; Huang, C.; Shinde, S.; Switnicka-Plake, M.; Cormacke, P. A. G.; Sellergren, B.* Reflux precipitation polymerization: a new synthetic insight in molecular imprinting at high temperature; RSC Adv.2016, 6, 81491-81499. (IF= 3.108, Times Cited: 2)

 

(11) Shen, X.*; Huang, C.; Shinde, S.; Jagadeesan, K. K.; Ekström, S.; Fritz, E.; Sellergren, B.* Catalytic Formation of Disulfide Bonds in Peptides by Molecularly Imprinted Microgels at Oil/Water Interfaces; ACS Appl. Mater. Interfaces2016, 8, 30484-30491. (IF= 7.504, Times Cited: 12)

 

(12) Huang, C.; Seip, K. F.; Gjelstad, A.; Shen, X.*; Pedersen-Bjergaard, S. Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Step: Simultaneous Group Separation of Acidic and Basic Drugs; Anal. Chem.2015, 87, 6951-6957. (IF= 6.320, Times Cited: 20)

 

(13) Shen, X.; Bonde, J. S.; Kamra, T.; Bülow, L.; Leo, J. C.; Linke, D.; Ye, L. Bacterial Imprinting at Pickering Emulsion Interfaces; Angew. Chem., Int. Ed., 2014, 53, 10687-10690. (IF= 13.734, Times Cited: 51)

 

(14) Tu, Z.; Tang, H.; Shen, X.*, Particle-assisted semidirect breath figure method: A facile way to endow the honeycomb-structured Petri dish with molecular recognition capability; ACS Appl. Mater. Interfaces2014, 6, 12931-12938. (IF= 7.504, Times Cited: 10)

 

(15) Huang, C.; Shen, X.*, Janus molecularly imprinted polymer particles; Chem. Commun.201450, 2646-2649. (IF= 6.378, Times Cited: 33)

 

(16) Huang, C.; Shen, X.*, Breath figure patterns made easy; ACS Appl. Mater. Interfaces20146, 5971-5976. (IF= 7.504, Times Cited: 25)

 

(17) Shen, X.; Xu, C., Uddin, K. M. A.; Larsson, P.-O.; Ye, L., Molecular recognition with colloidosomes enabled by imprinted polymer nanoparticles and fluorogenic boronic acid. J. Mater. Chem., B20131, 4612-4618. (IF= 6.101, Times Cited: 22)

 

(18) Zhou, T.; Shen, X.*; Shilpi, C.; Ye, L., Molecularly imprinted polymer beads prepared by pickering emulsion polymerization for steroid recognition. J. Appl. Polym. Sci.2014131, 39606. (IF= 1.395, Times Cited: 29)

 

(19) Shen, X.; Zhu, L.; Wang, N.; Zhang, T.; Tang, H., Selective photocatalytic degradation of nitrobenzene facilitated by molecular imprinting with a transition state analog. Catal. Today2014225, 164-170. (IF= 2.98, Times Cited: 33)

 

(20) Huang, C., Tu, Z.; Shen, X.*, Molecularly imprinted photocatalyst with a structural analogue of template and its application. J. Hazard. Mater., 2013248-249, 379-386. (IF= 3.925, Times Cited: 23)

 

(21) Shen, X.; Xu, C.; Ye, L., Molecularly imprinted polymers for clean water: Analysis and purification. Ind. Eng. Chem. Res., 201352, 13890-13899. (IF= 2.206, Times Cited: 32)

 

(22) Shen, X.; Zhou, T.; Ye, L., Molecular imprinting of protein in Pickering emulsion. Chem. Commun.2012, 488198-8200. (IF= 6.378, Times Cited: 73)

 

(23) Shen, X.; Xu, C.; Ye, L., Imprinted polymer beads enabling direct and selective molecular separation in water. Soft Matter, 20128, 3169-3176. (IF= 3.909, Times Cited: 45)

 

(24) Xu, C.; Shen, X. (co-first author); Ye, L., Molecularly imprinted magnetic materials prepared from modular and clickable nanoparticles. J. Mater. Chem., 201222, 7427-7433. (IF= 6.101, Times Cited: 32)

 

(25) Shen, X.; Zhu, L.; Wang, N.; Ye, L.; Tang, H., Molecular imprinting for removing highly toxic organic pollutants. Chem. Commun., 2012, 48, 788-798. (IF= 6.378, Times Cited: 91)

 

(26) Tang, H.; Zhu, L.; Yu, C.; Shen, X.*, Selective photocatalysis mediated by magnetic molecularly imprinted polymers. Sep. Purif. Technol., 2012, 95, 165-171. (IF= 2.894, Times Cited: 28)

 

(27) Shen, X.; Ye, L., Molecular imprinting in Pickering emulsions: a new insight into molecular recognition in water. Chem. Commun.201147, 10359-10361. (IF= 6.378, Times Cited: 66)

 

(28) Shen, X.; Ye, L., Interfacial molecular imprinting in nanoparticle-stabilized emulsions. Macromolecules2011, 44, 5631-5637. (IF= 5.521, Times Cited: 83)

 

(29) Shen, X.; Zhu, L.; Huang, C.; Tang, H., Yu, Z.; Deng, F., Inorganic molecular imprinted titanium dioxide photocatalyst: synthesis, characterization and its application for efficient and selective degradation of phthalate esters. J. Mater. Chem., 2009, 19, 4843-4851. (IF= 6.101, Times Cited: 80)

 

(30) Shen, X.; Zhu, L.; Yu, H.; Tang, H.; Liu, S.; Li, W., Selective photocatalysis on molecular imprinted TiO2 thin films prepared via an improved liquid phase deposition method. New J. Chem., 2009, 33, 1673-1679. (IF= 2.966, Times Cited: 37)

 

(31) Shen, X.; Zhu, L.; Liu, G.; Tang, H., Liu, S.; Li, W., Photocatalytic removal of pentachlorophenol by means of an enzyme-like molecular imprinted photocatalyst and inhibition of the generation of highly toxic intermediates. New J. Chem., 2009, 33, 2278-2285. (IF= 2.966, Times Cited: 25)

 

(32) Shen, X.; Zhu, L.; Liu, G.; Yu, H.; Tang, H., Enhanced photocatalytic degradation and selective removal of nitrophenols by using surface molecular imprinted titania. Environ. Sci. Technol., 2008, 42, 1687-1692. (IF= 5.257, Times Cited: 153)

 

(33) Shen, X.; Zhu, L.; Li, J.; Tang, H., Synthesis of molecular imprinted polymer coated photocatalysts with high selectivity. Chem. Commun., 2007, 11, 1163-1165. (IF= 6.378, Times Cited: 91)

 

(34) Guo, Q.; Shen, X.; Li, Y.; Xu, S.; Carbon nanotubes-based drug delivery to cancer and brain. Current Medical Science,2017,37(5), 635-641. (IF= 0.948, Times Cited: 3)

 

(35) Restan, MS., Jensen, H., Shen, X., Huang, C., Martinsen, ØG., Kubáň, P., Gjelstad, A., Pedersen-Bjergaard, S., Comprehensive study of buffer systems and local pH effects in electromembrane extraction. Anal. Chim. Acta., 2018, 984, 116-123.(IF=5.123, Times Cited: 12)

 

(36) Ye, L., Zhou, T., Shen, X., Molecular imprinting in particle-stabilized emulsions: enlarging template size from small molecules to proteins and cells. Molecular Imprinting, 2016, 3(1), 8-16. (Times Cited: 2)

 

(37) Huang, C.; Eng E., Lars E.; Gjelstad, A.; Shen, X.; Trones, R.; Jensen, H.; Pedersen-Bjergaard, S., Development of a flat membrane based device for electromembrane extraction: a new approach for exhaustive extraction of basic drugs from human plasma. J. Chromatogr. A2014, 1326, 7-12. (IF= 4.449, Times Cited: 47)

 

(38) Xu, C., Uddin, K. M. A.; Shen, X.; Jayawarden, H. S., Yan, M.; Ye, L., Photoconjugation of molecularly imprinted polymer with magnetic nanoparticles. ACS Appl. Mater. Interfaces20135, 5208-5213. (IF= 5.008, Times Cited: 33)

 

(39) Li, Ji; Tang, H.; Zhang, Ai; Shen, X.; Zhu, L., A new strategy for the synthesis of polyaniline nanostructures: From nanofibers to nanowires. Macro. Rap. Comm., 2007, 28, 740-745. (IF= 4.929, Times Cited: 48)

 

(40) Wang, N.; Xu, Y.; Zhu, L.; Shen, X.; Tang, H., Reconsideration to the deactivation of TiO2 catalyst during simultaneous photocatalytic reduction of Cr(VI) and oxidation of salicylic acid. J. Photochem. Photobiol. A: Chem., 2009, 201, 121-127. (IF= 2.416, Times Cited: 68)



二、 中文文章

      (1) 江龙沈先涛*基于 Pickering 乳液的分子印迹技术科学通报, 2018, 63

 

(2) 常青沈先涛王佳朱丽华液相微萃取-气相色谱法测定水样中痕量酚类污染物理化检验-化学分册 2008, 44: 11-13



三、 专著

(1) Shen, X.; Huang, C.; Ye, L., Generation of Janus Molecularly Imprinted Polymer Particles. In Synthetic Antibodies. 2017, 353-362 (Humana Press)

 

(2) Shen, X., Molecularly Imprinted Catalysts, Molecularly Imprinted Photocatalysts. 2016,.211-228 (Elsevier)



四、 专利

(1) 沈先涛陈志亮刘小杰一种光还原六价铬的离子印迹聚合物材料及其制备和应用国家发明专利申请号: 201710534799.6

 

(2) 朱丽华沈先涛唐和清,人工抗体型复合光催化剂及其制备方法国家发明专利申请号: 200610019453.4

 

(3) 朱丽华罗玮沈先涛唐和清一种SiO2颗粒表面分子印迹吸附剂及其制备方法国家发明专利申请号: 200810046661.2


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